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The Surprising Link Between Oral Health, Brain Function, and Overall Wellness: Insights from the Huberman Lab Podcast

Wednesday, March 26, 2025

When we think about health, we often focus on diet, exercise, or sleep—but how often do we consider our oral health? In a recent episode of the Huberman Lab podcast, neuroscientist Dr. Andrew Huberman and Dentist Dr. Staci Whitman dive deep into the fascinating world of the oral microbiome and its profound impact on brain and body health. From cavities to cardiovascular disease, fertility to dementia, the state of your mouth plays a bigger role in your overall wellness than you might think. Here’s what we learned from this eye-opening episode—and how you can apply these science-backed insights to improve your oral health today.

The Oral Microbiome: A Hidden Key to Brain and Body Health

Your mouth is home to over 700 bacterial species, collectively known as the oral microbiome. As Dr. Whitman explains, this ecosystem isn’t just about keeping your teeth clean—it’s a gateway to your overall health. Through the vagus nerve (a biological “information highway” discovered by Pavlov in 1889), the oral microbiome communicates directly with your brain, influencing mood, cognition, and even systemic diseases.

  • Why It Matters: An imbalanced oral microbiome can lead to cavities, gum disease, and inflammation that contributes to conditions like dementia, heart disease, and cancer. 
  • Fun Fact: The oral microbiome produces neurotransmitters that affect brain function, as noted by Nobel laureate Joshua Lederberg in 2001.
Cavities and Remineralization: It’s All About Balance

Cavities form when demineralization (the loss of minerals from your enamel) outpaces remineralization (the natural repair process). While fluoride in toothpaste and water can help remineralize teeth, Dr. Whitman emphasizes that diet and habits play a massive role in preventing decay. 

  • Diet Tips for Healthy Teeth:
    • Cut back on sugar and “dissolvable” carbs (like crackers or candy) that feed cavity-causing bacteria.
    • Eat whole foods and “feed the rainbow” to support a healthy oral environment.
    • Space out meals and avoid frequent snacking—fasting periods give your teeth a chance to remineralize.
  • Fluoride’s Role: Fluoride creates a stronger, acid-resistant layer of fluorapatite on your enamel, slowing cavity formation. However, balance is key (more on that later). 
Oral Care Products: What to Avoid and What to Use

Not all oral care products are created equal. Dr. Whitman warns against ingredients that can harm your oral microbiome and overall health.

  • What to Avoid:
    • Alcohol-Based Mouthwashes: These can disrupt your oral microbiome, increase cardiovascular risks, and dry out your mouth, leading to bad breath.
    • Sodium Lauryl Sulfate (SLS): Found in many toothpastes, SLS can cause canker sores and irritation, especially for sensitive mouths.
  • Better Alternatives:
    • Switch to hydroxyapatite toothpaste, a natural mineral that whitens teeth and strengthens enamel without the risks of fluoride or SLS.
    • Use alcohol-free mouthwashes to maintain a healthy microbial balance. 
Nasal Breathing: A Game-Changer for Saliva and Oral Health

Did you know how you breathe impacts your oral health? Dr. Whitman highlights the benefits of nasal breathing over mouth breathing: 

  • Why Nasal Breathing Wins: It stimulates saliva production, which naturally fights bacteria, prevents tooth decay, and keeps your mouth hydrated. Mouth breathing, especially during sleep, dries out your mouth and creates a breeding ground for bacteria.
  • Practical Tools:
    • Try mouth taping at night to encourage nasal breathing (start with a small piece of medical tape). 
    • Practice the “3-Minute Test” or “Kiss the Sky” exercise to train yourself to nasal breathe during the day.

  • Bonus: Nasal breathing can also improve sleep quality and reduce the risk of sleep disorders linked to mouth breathing, like snoring or sleep apnea.

Gum Health: The Link to Heart Disease, Dementia, and Cancer

Your gums are more than just a foundation for your teeth—they’re a window into your systemic health. Dr. Whitman introduces the concept of “leaky gums,” where poor gum health allows bacteria to enter the bloodstream, contributing to serious conditions.

  • The Risks: Gum disease is linked to cardiovascular disease, dementia, and even cancer due to chronic inflammation.
  • How to Protect Your Gums: 
    • Floss daily to remove plaque and bacteria between teeth.
    • Consider probiotics to support a healthy oral and gut microbiome.
    • Address issues like a deviated septum, which can lead to mouth breathing and exacerbate gum problems. 
The Fluoride Debate: Benefits vs. Risks

Fluoride has long been hailed as a cavity-fighting hero, but Dr. Whitman and Dr. Huberman explore its potential downsides. 

  •  The Benefits: Fluoride in water and toothpaste helps remineralize enamel and creates a more acid-resistant surface, slowing cavity formation. 
  • The Risks: High levels of fluoride (from water fluoridation or overexposure) may pose neurocognitive risks, particularly for children. Some studies suggest a link to lower IQ scores in areas with excessive fluoride. 
  • What to Do: If you’re concerned, opt for fluoride-free alternatives like hydroxyapatite toothpaste. Test your local water for fluoride levels to make an informed choice.
Oral Health and Fertility: A Surprising Connection

Here’s a surprising takeaway: your oral health can impact your fertility. Dr. Whitman explains that gum disease and poor oral hygiene can affect pregnancy outcomes and hormonal health.

  • For Women: During pregnancy, hormonal changes can increase the risk of gum inflammation. Poor oral health is also linked to preterm birth and low birth weight.
  • For Men: Gum disease can contribute to systemic inflammation, which may affect sperm quality. 
  • Action Step: Prioritize flossing, brushing, and a clean diet to support your reproductive health. 
Special Topics: Pregnancy, Menopause, and Tongue Ties

Dr. Whitman also touches on how oral health evolves across life stages:

  • Pregnancy and Menopause: Hormonal shifts can lead to issues like burning mouth syndrome or increased gum sensitivity. Stay consistent with oral care during these times.
  • Tongue Ties in Kids: A tongue tie can affect speech, chewing, and facial development. Early intervention (like myofunctional therapy) can help. 
  • Mouth Breathing in Kids: Chronic mouth breathing can lead to hard and soft tissue issues, sleep disorders, and asymmetrical facial growth. Encourage nasal breathing early. 
Practical Tools to Optimize Your Oral Health

Ready to take action? Here are Dr. Whitman’s top science-backed tools for a healthier mouth: 

  • Chew Xylitol Gum: Xylitol inhibits cavity-causing bacteria and stimulates saliva production. 
  • Use Hydroxyapatite Toothpaste: An alternative to fluoride for whitening and strengthening enamel. 
  • Nasal Breathe: Make it a habit to improve saliva flow and reduce dry mouth.
  • Floss Daily: Don’t skip this step—it’s crucial for gum health. 
  • Test Your Oral Microbiome: Services like Bristle Health can analyze your oral bacteria and provide personalized recommendations. 
  • Limit Antibiotics: Overuse can disrupt your oral-gut microbiome axis, so use them only when necessary.
Why This Matters: Oral Health Is Whole-Body Health

This episode of the Huberman Lab podcast is a powerful reminder that oral health isn’t just about a bright smile—it’s a cornerstone of overall wellness. From supporting brain function to reducing the risk of chronic diseases, taking care of your mouth has far-reaching benefits. As Dr. Huberman and Dr. Whitman emphasize, small, consistent habits—like nasal breathing, flossing, and choosing the right products—can make a big difference.

Take Action: Listen and Share Your Tips

Want to dive deeper? Listen to the full episode of the Huberman Lab podcast with Dr. Staci Whitman, available on X, YouTube, Apple Podcasts, Spotify, and other platforms. Dr. Whitman’s holistic approach to dentistry and Dr. Huberman’s knack for breaking down complex science make this a must-listen for anyone interested in health and longevity. 

If you found this post helpful, share it with a friend who might need a nudge to prioritize their oral health.